Medulloblastoma with extensive nodularity (SHH medulloblastoma)
نویسندگان
چکیده
منابع مشابه
Medulloblastoma with extensive nodularity: single photon emission CT study with iodine-123 metaiodobenzylguanidine.
We present the case of an infant with medulloblastoma with extensive nodularity, which had been called cerebellar neuroblastoma. MR imaging clearly revealed a nodular enhancement, which appeared as a grape-like lesion. Single photon emission CT revealed markedly high iodine-123 metaiodobenzylguanidine uptake in the enhancing tumor. Iodine-123 metaiodobenzylguanidine single photon emission CT ma...
متن کاملMedulloblastoma With Extensive Nodularity: Tailored Therapy in a Low-resource Setting.
Treatment for medulloblastoma carries significant risks, particularly in resource-constrained settings. We report a case of a Mexican infant with desmoplastic/nodular medulloblastoma. Given the nature of her tumor, we developed a tailored regimen following subtotal resection to avoid both radiation therapy and the high-dose cisplatin therapy offered at most centers in the United States. The pat...
متن کاملA rare case of medulloblastoma with excessive nodularity: imagistic features
Medulloblastoma is the most common malignant tumor of childhood. Neuroimaging can play a role in the diagnosis of medulloblastoma, however atypical features do exist [2]. We report the case of a 1 year and 10month-old infant diagnosed with a medulloblastoma with what we term “excessive” nodularity based on neuroimaging features and confirmed by neuropathology. CT-scan (CT) and magnetic resonanc...
متن کاملMedulloblastoma with Excessive Nodularity: Radiographic Features and Pathologic Correlate
Medulloblastoma with extensive nodularity is a rare subtype of the most common malignant childhood brain tumor and has been associated with more favorable prognosis. The authors report the case of a 10-month-old girl with a posterior fossa tumor of excessive nodularity with decreased diffusivity on diffusion-weighted magnetic resonance imaging sequences and robust grape-like postgadolinium cont...
متن کاملEvasion of cell senescence in SHH medulloblastoma
The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1+/- mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event associated with cell senescence in preneoplasia. Subsequently, p53 mutations lead to senescence evas...
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ژورنال
عنوان ژورنال: Polish Journal of Pathology
سال: 2017
ISSN: 1233-9687
DOI: 10.5114/pjp.2017.73934